Changes in reward contingency modulate the trial-to-trial variability of hippocampal place cells.

Andrew M . Wikenheiser and A . David Redish trial - to - trial variability of hippocampal place cells Changes in reward contingency modulate the

1 2 3 4 5 6 7 8 9 10 Changes in reward contingency modulate the trial to trial variability of 11 hippocampal place cells 12 Andrew

44 Pyramidal cells in the rodent hippocampus often exhibit clear spatial tuning. Theories of 45 hippocampal function suggest these ‘place’ cells implement multiple, independent neural 46 representations of position (maps), based on different reference frames or environmental 47 features. Consistent with the ‘multiple maps’ theory, previous studies have shown that 48 manipulating spatial factors...

Hippocampal place cells can encode multiple trial-dependent features through rate remapping.

The activity of hippocampal pyramidal cells reflects both the current position of the animal and information related to its current behavior. Here we investigated whether single hippocampal neurons can encode several independent features defining trials during a memory task. We also tested whether task-related information is represented by partial remapping of the place cell population or, inst...

Immediate changes in anticipatory activity of caudate neurons associated with reversal of position-reward contingency.

The primate caudate nucleus plays a crucial role in transforming cognitive/motivational information into eye movement signals. A subset of caudate projection neurons fire before a visual target's onset. This anticipatory activity is sensitive to position-reward contingencies and correlates with saccade latency, which is shorter toward a rewarded position. We recorded single-unit activity of cau...

Trial Outcome and Associative Learning Signals in the Monkey Hippocampus

In tasks of associative learning, animals establish new links between unrelated items by using information about trial outcome to strengthen correct/rewarded associations and modify incorrect/unrewarded ones. To study how hippocampal neurons convey information about reward and trial outcome during new associative learning, we recorded hippocampal neurons as monkeys learned novel object-place as...